國立政治大學神經科學研究所

期刊論文

• Chang WT;Lee MY;Wang YJ;Huang WC;Hsiesh CP;Tung CW;Chan MH*;Chen HH, 2025.08, 'A New Perspective on Betaine: Targeting the Glycine Binding Site of the NMDA Receptor., ' Biochemical Pharmacology, No.242, pp.117213.(SCI)(*為通訊作者)
• Wang YJ*;Hwang E;Chen HH*;Chan MH*;Yeh CJ;Liu YX;Huang CH, 2025.03, 'Fluvastatin, an HMG-CoA reductase inhibitor, exerts protective effect against NMDA-induced seizure by increasing the seizure threshold and modulating membrane excitability in embryonic rat cortical neuron., ' Brain Research., No.1, pp.1850.(SCI)(*為通訊作者)
• B. Muhammed;V. Michael;Chan MH;K. Mohammed;S. Chang*, 2025.02, 'Alcohol consumption modulates the development of chronic pain in COVID-19 patients: A Network Meta-analysis., ' ACS Pharmacology & Translational Science., Vol.8, pp.409-422.(SCI)(*為通訊作者)
• Chen LC;Chan MH*;Chen HH*, 2024.06, 'Comparative Assessment of the Addictive Potential of Synthetic Cathinones by Zebrafish Conditioned Place Preference (CPP) Paradigm. Life, ' Life, Vol.14, No.7, pp.820.(SCI)(*為通訊作者)
• Chen LC;Chen HH;Chan MH*, 2024.06, 'Calcium channel inhibitor and extracellular calcium improve aminoglycoside‑induced hair cell loss in zebrafish., ' Archives of Toxicology, Vol.98, No.6, pp.1827-1842.(SCI)(*為通訊作者)
• Chen LC;Chan MH;Chen HH*, 2023.12, 'Extinction and reinstatement of methamphetamine induced conditioned place preference in zebrafish., ' Addiction Biology, Vol.28, No.12, pp.e13351.(SCI)(*為通訊作者)
• Shiao YC;Lee MY;Chan MH;Chen HH*, 2023.05, 'NMDA receptor glycine binding site modulators for prevention and treatment of ketamine use disorder., ' Pharmaceuticals, Vol.16, pp.812.(SCI)(*為通訊作者)
• Sung CW;Chang WT;Chan MH;Kuo TH*;Chen HH*, 2022.11, 'L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice., ' Biomedicine &Pharmacotherapy,, Vol.155, pp.113726.(SCI)(*為通訊作者)
• Lee MY;Hsieh CP;Chan MH;Chen HH*, 2022.11, 'Beneficial effects of atypical antipsychotics on object recognition deficits after adolescent toluene exposure in mice: involvement of 5-HT1A receptors., ' Am J Drug Alcohol Abuse, Vol.22, pp.1-11.(SCI)(*為通訊作者)
• Chen ST;Hsieh CP;Lee MY;Chen LC;Huang CM;Chen HH**;Chan MH**, 2021.12, 'Betaine prevents and reverses the behavioral deficits and synaptic dysfunction induced by repeated ketamine exposure in mice, ' Biomedicine &Pharmacotherapy,, Vol.144, pp.112369..(SCI)(*為通訊作者)
• Szkudelska K;Chan MH;Okulicz M;Jasaszwili M;Szkudelski T*, 2021.10, 'Betaine supplementation to rats alleviates disturbances induced by high-fat diet: pleiotropic effects in model of type 2 diabetes., ' Journal of Physiology and Pharmacology, Vol.72, No.5, pp.763-775..(SCI)(*為通訊作者)
• Hsieh CP;Chen ST;Lee MY;Huang CM;Chen HH;Chan MH**, 2021.09, 'N, N-dimethylglycine Protects Behavioral Disturbances and Synaptic Deficits Induced by Repeated Ketamine Exposure in Mice, ' Neuroscience,, Vol.472, pp.128-137.(SCI)(*為通訊作者)
• Hsieh CP;Chang WT;Chen L;Chen HH;Chan MH*, 2021.07, 'Differential inhibitory effects of resveratrol on excitotoxicity and synaptic plasticity: involvement of NMDA receptor subtypes., ' Nutritional Neuroscience, No.22, pp.1-16.(SCI)(*為通訊作者)
• Lee MY;Lin BF;Chan MH*;Chen HH*, 2020.12, 'Increased behavioral and neuronal responses to a hallucinogenic drug after adolescent toluene exposure in mice: effects of antipsychotic treatment., ' Toxicology, No.445, pp.152602.(SCI)(*為通訊作者)
• Hsieh CP;Chen H;Chan MH;Chen L;Chen HH*, 2020.12, 'N,Ndimethylglycine prevents toluene-induced impairment in recognition memory and synaptic plasticity in mice., ' Toxicology, No.446, pp.152613.(SCI)(*為通訊作者)
• Chan MH;Chen HH;Lo YC;Wu SN*, 2020.06, 'Effectiveness in the block by honokiol. A dimerized allylphenol from Magnonia officinalis, of Hyperpolarization-activated cation current and delayed-rectifier K+ current., ' Int J Mol Sci, No.21, pp.4260.(SCI)(*為通訊作者)
• Lee MY;Hsiao YC;Chan MH;Chen HH*, 2019.01, 'Lamotrigine attenuates the motivation to self-administer ketamine and prevents cue- and prime-induced reinstatement of ketamine-seeking behavior in rats, ' Drug and Alcohol Dependence, No.194, pp.257-263.(SCI)(*為通訊作者)
• Chen HH;Chang PC;Wey SP;Chen PM;Chen C;Chan MH*, 2018.12, 'Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARr regulation, ' Biomedicine & Pharmacotherapy, No.108, pp.254-262.(SCI)(*為通訊作者)
• Wu CY;Tsai YL;Hsieh CP;Wang TC;Chan MH*;Chen HH*, 2018.09, 'Attenuation of toluene-induced brain stimulation reward enhancement and behavioral disturbances by N-acetylcysteine in mice, ' Toxicology, Vol.21, No.408, pp.39-45.(SCI)(*為通訊作者)
• Chen HH;Chang PC;Chen C;Chan MH*, 2018.08, 'Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson’s disease, ' Pharmacological Reports, Vol.70, No.4, pp.668-676.(SCI)(*為通訊作者)
• Wang YJ;Hsieh CP;Chan MH;Chan TY;Chen L;Chen HH*, 2018.04, 'Distinct effects of resveratrol on seizures and hyperexcitability induced by NMDA and 4- aminopyridine, ' Nutritional Neuroscience, No.12, pp.1-11.(SCI)(*為通訊作者)
• Wu SN;Chern JH;Shen S;Chen HH;Hsu YT;Lee CC, 2017.12, 'Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels, ' J Cell Physiol, Vol.232, No.12, pp.3409-21.(SCI)
• Lin YR;Peng KC;Chan MH;Peng HL;Liu SY*, 2017.12, 'Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivo., ' J Agric Food Chem, No.65, pp.10489-10494.(SCI)(*為通訊作者)
• Weng CC;Chen ZA;Chao KT;Ee TW;Lin KJ;Chan MH, 2017.05, 'Quantitative Analysis of the Therapeutic Effect of Magnolol on MPTP-Induced Mouse Model of Parkinson’s Disease Using In Vivo 18F-9-Fluoropropyl-(+)-Dihydrotetrabenazine PET Imaging, ' PLoS One, Vol.12, No.3, pp.e0173503.(SCI)
• Lee MY;Lin YR;Tu YS;Tseng YJ;Chan MH**;Chen HH**, 2017.02, 'Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials, ' J Biomed Sci, Vol.24, No.1, pp.18.(SCI)(*為通訊作者)
• Lin J;Chan MH;Lee MY;Chen YC;Chen HH*, 2016.11, 'N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice, ' Prog Neuropsychopharmacol Biol Psychiatry., Vol.71, pp.7-13.(SCI)(*為通訊作者)
• Lin J;Lee MY;Chan MH;Chen YC;Chen HH*, 2016.09, 'Betaine enhances antidepressant-like, but blocks psychotomimetic effects of ketamine in mice, ' Psychopharmacology, Vol.233, pp.3223-35.(SCI)(*為通訊作者)
• Wang YJ;Chan MH;Chen L;Wu SN;Chen HH*, 2016.05, 'Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels, ' J Biomed Sci, Vol.23, pp.47.(SCI)(*為通訊作者)
• Shen YL;Chen ST;Chan TY;Hung TW;Tao PL;Liao RM;Chan MH;Chen HH*, 2016.02, 'Delayed extinction and stronger drug-primed reinstatement of methamphetamine seeking in rats prenatally exposed to morphine, ' Neurobiology of learning and Memory, Vol.128, pp.56-64.(SCI)(*為通訊作者)
• Chan MH;Tsai YL;Lee MY;Stoker A;Markou A;Chen, HH*, 2015.09, 'The group II metabotropic glutamate receptor agonist LY379268 reduces toluene-induced enhancement of brain-stimulation reward and behavioral disturbances, ' Psychopharmacology, Vol.232, pp.3259-3268.(SCI)(*為通訊作者)
• Wu, CY;Lee, HJ;Liu, CF;Korivi, M;Chen HH;Chan MH*, 2015, 'Protective role of L-ascorbic acid, N-acetylcysteine, and apocynin on neomycin-induced hair cell loss in Zebrafish., ' Journal of Applied Toxicology, No.35, pp.273-279.(SCI)(*為通訊作者)
• Liu, B.R.;Chen, H.H.;Chan, M.H.;Huang, Y.W.;Aronstam R.S;Lee, H.J.*, 2015, 'Three arginine-rich cell-penetrating peptides facilitate cellular internalization of red-emitting quantum dots, ' Journal of Nanoscience and Nanotechnology, No.15, pp.2067-2078.(SCI)(*為通訊作者)
• Chiu, HY;Chan, MH;Lee, MY;Chen, ST;Zhan, ZY;Chen, HH.*, 2014.10, 'Long-lasting alterations in 5-HT2A receptor after a binge regimen of methamphetamine in mice, ' International Journal of Neuropsychopharmacology, Vol.17, No.10, pp.1647-1658.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Mei-Yi Lee;Chun-Cheng Chiang;Hong-Yi Chiu;Ming-Huan Chan;Hwei-Hsien Chen*, 2014.02, 'N-acetylcysteine modulates hallucinogenic 5-HT2A receptor agonist-mediated responses: Behavior, molecular, and electrophysiological studies., ' Neuropharmacology, Vol.15, No.81, pp.215-223.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Wang YJ;Chan MH*;Chen HH, 2013.11, 'Methamphetamine inhibits voltage-gated potassium currents in NG108-15 cells: Possible contribution of large-conductance calcium-activated potassium channels, ' Toxicol Letters, Vol.223, No.2, pp.139-145.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Wang, H.J.;Martin, A.G.;Chao, P.K.;...;Chan, M.-H.*;Aronstam, R.S.*, 2013.02, 'Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling., ' Journal of Biomedical Science, Vol.20, No.1, pp.11.(SCI)(*為通訊作者)
• Liu, B.R.;Chiang, H.J.;Huang, Y.W.;Chan, M.-H.;...;Lee, H.-J*, 2013.01, 'Cellular Internalization of Quantum Dots Mediated by Cell-Penetrating, ' Pharmaceutical Nanotechnology, Vol.1, No.2, pp.151-161.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Chuang, D.Y.;Chan, M.-H.#;Zong, Y;...;Sun, A.Y.;Sun, G.Y*, 2013.01, 'Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells., ' Journal of Neuroinflammation, Vol.29, No.10, pp.15.(SCI)(*為通訊作者)
• Chan MH;Lee CC;Lin BF;Wu CY;Chen HH*, 2012.12, 'Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats, ' Pharmacol Biochem Behav, Vol.103, No.2, pp.418-424.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Chan MH;Chung SS;Stoker AK;Markou A;Chen HH*, 2012.12, 'Sarcosine attenuates toluene-induced motor incoordination, memory impairment, and hypothermia but not brain stimulation reward enhancement in mice, ' Toxicol Appl Pharmacol, Vol.265, No.2, pp.158-165.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Harada S.;Kishimoto M.;...;Chen H.-H.;Chan, M.-H.;Tokuyama S*, 2012.10, 'Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice, ' Journal of Natural Medicines, Vol.66, No.4, pp.591-599.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Chan, MH;Chiu, PH;Lin, CY;Chen, HH*, 2012.04, 'Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine, ' Schizophr Res, Vol.136, No.1, pp.96-103.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Chen YJ;Liu BR;Dai YH;Lee CY;Chan MH;Lee HJ*, 2012.02, 'A gene delivery system for insect cells mediated by arginine-rich cell-penetrating peptides, ' Gene, Vol.493, No.2, pp.201-210.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Tripathi S;Chan MH*;Chen C*, 2012.01, 'An expedient synthesis of honokiol and its analogues as potential neuropreventive agents, ' Bioorg Med Chem Lett, Vol.22, No.1, pp.216-221.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• HH Chen;YR Lin;MH Chan*, 2011.09, 'Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-d-aspartate receptor-mediated currents in rat hippocampus, ' Toxicol. Lett, Vol.205, No.3, pp.336-340.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• Chen HH;Lin SC;Chan MH*, 2011.04, 'Protective and restorative effects of magnolol on neurotoxicity in mice with 6-hydroxydopamine-induced hemiparkinsonism, ' Neurodegener Dis, Vol.8, No.5, pp.364-374.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• HH Chen;PF Liao;MH Chan*, 2011.02, 'mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway, ' J. Biomed. Sci., Vol.18, No.1, pp.19.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• YR Lin;HH Chen;YC Lin;CH Ko;MH Chan*, 2009.10, 'Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain, ' J. Biomed. Sci, Vol.16, No.1, pp.94.(SCI)(*為通訊作者) 參考連結(另開新視窗)
• CC Su*;TL Chou;MH Chan;JG Lin, 2009.01, 'Astrgaloside IV increases MMP-2 mRNA and protein expression in human lung cancer A549 cells., ' Molecular Medicine Report, Vol.2, No.1, pp.107-113.(*為通訊作者) 參考連結(另開新視窗)

會議論文

• Chan MH*;Kuo TH;Chen LC;Chen HH, 2025.07, 'Protective Effects of Sodium Benzoate on Toluene-Induced Behavioral Disturbances and Synaptic Dysfunction in Mice., ' The 48th Annual Meeting of the Japan Neuroscience Society, The 48th Annual Meeting of the Japan Neuroscience Society.(*為通訊作者)
• Chan MH*;Chang MH;Chen CY;Chen HH, 2025.06, 'Priming with bupropion reinstates drug-seeking and enhances cue-induced reinstatement in male rats self-administering eutylone or N-ethylpentylone, ' The College on Problems of Drug Dependence (CPDD) 86th Annual Scientific meeting, CPDD.(*為通訊作者)
• Ming-Huan Chan*;Yi-Hsien Liu;Hwei-Hsien Chen, 2024.05, 'Effects of sodium benzoate on behavioral and synaptic deficits induced by subchronic ketamine exposure in mice, ' The 35th World Congress Collegium International Neuro-Psychopharmacologicum, CINP.(*為通訊作者)
• Chan MH*;Chang WT;Huang CM;Chen HH, 2023.07, '2-Fluorodeschloroketamine shares a similar pharmacological and behavioral profiles with ketamine in vitro and in vivo studies, ' The 19th World Congress of Basic and Clinical Pharmacology, IUPHAR.(*為通訊作者)
• Chan MH*;Lou YZ;Hung YT;Chen HH, 2022.11, 'The analgesic mechanisms of trimethylglycine on cisplatin-induced neuropathic pain in mice, ' The 52th Society for Neuroscience Annual Meeting, Society for Neuroscience.(*為通訊作者)
• 詹銘煥*, 2022.06, 'Extracellular calcium and calcium channel modulators alter aminoglycoside-induced hair cell loss in zebrafish, ' The 17th International Zebrafish Conference 2022, International zebrafish society.(*為通訊作者)
• 詹銘煥*, 2019.10, 'Combined treatment with dimethylglycine attenuates the behavioral deficits induced by repeated ketamine exposure, ' The 6th Congress of Asia College of Neuropsychopharmacology, AsCNP Congress.(*為通訊作者)
• 詹銘煥*, 2019.06, 'Dimethylglycine alleviates behavioral disturbances induced by adolescent toluene exposure, '.(*為通訊作者)
• Hung YT;Chen SK;Chang JM;Chiu HH;Chan MH*, 2018.07, 'NMDA receptor modulator rescues psychiatric phenotypes in mouse model of maternal immune activation, ' The 18th Worldl Congress of Basic and Clinical Pharmacology, World Congress of Pharmacology.(*為通訊作者)
• Chan MH*;Lin CY;Chen HH, 2018.06, 'Sodium benzoate reduced toluene-induced behavioral disturbance and faciliation of brain stimulation reward, ' The 8th International Congress of Asian Society of Toxicology, ASIATOX.(*為通訊作者)
• Hsieh CP;Chen H;Lee MY;Chan MH;Chen HH*, 2018.06, 'N.N-dimethylglycine ameliorates toluene-induced impairments in recognition memory and hippocampal long-term potentiation, ' The 8th International Congress of Asian Society of Toxicology, ASIATOX.(*為通訊作者)
• WT Chang;CP Hsieh;MH Chan*;HH Chen*, 2018, 'Effects of N-methylated derivatives of glycine on recombinant NMDA receptors expressed in HEK 293 cells, ' The 15th Meeting of the Asian-Pacific Society for Neurochemistry, Society for Neurochemistry.(*為通訊作者)
• Chan MH*, 2017.09, 'Reversal effects of sodium benzoate after a binge regimen of methamphetamine in mice, ' Recent Frontiers and Advances in Drug Addiction, International Drug abuse Research Society.(*為通訊作者)
• 詹銘煥*;CY Wu;CF Liu;HH　Ｃｈｅｎ, 2016.10, 'Extracellular calcium concentration and channel activity involved in aminoglycoside induced hair cell toxicity in the zebrafish lateral line, ' The XIV International Congress of Toxicology, Society of Toxicology.(*為通訊作者)
• 詹銘煥*;Ying-An Chen;Mei-Yi Lee;Hwei-Hsien Chen, 2015.08, 'Reversal effects of betaine and dimethylglycine on behavioral impairment after a binge regimen of methamphetamine in mice, ' The 4th APSAAR/5th IDARS conference, IDARS.(*為通訊作者)
• 詹銘煥*;Chian-Yu Lin;Hwei-Hsien Chen, 2015.07, 'Neuroprotection against oxidative stress and potentiation of neurite outgrowth by biphenolic compounds, '.(*為通訊作者)
• 詹銘煥*, 2014.07, 'The protective and therapeutic effects of cortex Magnoliae on neuronal damage and behavioral deficits induced by neurotoxin, ' 17th World Congress of Basic and Clinical Pharmacology (WCP2014), WCP.(*為通訊作者)
• Wang YJ;Chen HH;Chan MH*, 2013.10, 'Methamphetamine Inhibits Large Conductance Calcium-activated Potassium Channels in NG108-15 Neuroblastoma Cells, ' Special congress on addition and mental health.(*為通訊作者)
• Chan MH*;Huang CM;Chen HH, 2013.06, 'Protective effects of sodium benzoate on behavioral neurotoxicity induced by methamphetamine in mice, ' The XIII International Congress of Toxicology.(*為通訊作者)
• 詹銘煥*, 2012.09, 'Methamphetamine-induced cognitive deficits are improved by subsequent administration of pentoxifylline and clenbuterol, ' The 16th Congress of International Society for Biochemical Research on Alcoholism.(*為通訊作者)

專書篇章

• Liu BR;Chan MH;Chen HH;Lo SY;Huang YW;Lee HJ*, 2013.09, 'Effects of surface charge and particle size of cell-penetrating peptide/nanoparticle complexes on cellular internalization., ' Cell Membrane: Molecular Structure, Physiochemical Properties and Interactions with the Environment., Nova Science Publishers Inc., Hauppauge, New York, pp.43-57.(*為通訊作者) 參考連結(另開新視窗)
• Liu BR;Chan MH;Chen HH;Huang YW;Lee HJ*, 2013.09, 'Protein transduction in human cells mediated by arginine-rich cell-penetrating peptides in mixed covalent and noncovalent manners, ' In: Macromolecular Chemistry, Nova Science Publishers Inc., Hauppauge, New York., pp.69-82.(*為通訊作者)

校內本職

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 教授
• 神經科學研究所
• 2012年08月 ~

校內兼職

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 所長
• 神經科學研究所
• 2025年08月 ~ 2026年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 所長
• 神經科學研究所
• 2024年08月 ~ 2025年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 所長
• 神經科學研究所
• 2017年08月 ~ 2018年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 副院長
• 理學院
• 2016年08月 ~ 2017年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 所長
• 神經科學研究所
• 2016年08月 ~ 2017年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 副院長
• 理學院
• 2015年08月 ~ 2016年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 所長
• 神經科學研究所
• 2015年08月 ~ 2016年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 所長
• 神經科學研究所
• 2014年08月 ~ 2015年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 所長
• 神經科學研究所
• 2013年08月 ~ 2014年07月

• 職稱
• 部門/系所
• 擔任職務
• 起迄年月

• 所長
• 神經科學研究所
• 2012年08月 ~ 2013年07月